Enantioselective synthesis of cyclic sulfamidates via Pd-catalyzed hydrogenation.
نویسندگان
چکیده
Using Pd(CF3CO2) 2/(S,S)-f-binaphane as the catalyst, an efficient enantioselective synthesis of cyclic sulfamidates was developed via asymmetric hydrogenation of the corresponding cyclic imines in 2,2,2-trifluoroethanol at room temperature with high enantioselectivities (up to 99% ee).
منابع مشابه
Highly enantioselective synthesis of cyclic sulfamidates and sulfamides via rhodium-catalyzed transfer hydrogenation.
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Using pd(cf(3)co(2))2/(S,S)-f-Binaphane as the catalyst, an efficient enantioselective synthesis of sultams was developed via asymmetric hydrogenation of the corresponding cyclic imines with high enantioselectivities. The hydrogenation products can be conveniently transformed to chiral homoallylic amines without loss of enantioselectivity.
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Transition-metal-catalyzed asymmetric synthesis is a powerful and commonly used method for preparing a wide range of enantiomerically pure compounds.1 Among organo-transition-metal compounds, Pd complexes have become indispensable tools for both common and stateof-the art organic synthesis.2 Although a large number of Pd-based catalytic systems have been developed for many kinds of reactions, P...
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عنوان ژورنال:
- Organic letters
دوره 10 10 شماره
صفحات -
تاریخ انتشار 2008